🍩 Database of Original & Non-Theoretical Uses of Topology
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Topological Biomarkers for Real-Time Detection of Epileptic Seizures (2022)
Ximena Fernández, Diego MateosAbstract
Automated seizure detection is a fundamental problem in computational neuroscience towards diagnosis and treatment's improvement of epileptic disease. We propose a real-time computational method for automated tracking and detection of epileptic seizures from raw neurophysiological recordings. Our mechanism is based on the topological analysis of the sliding-window embedding of the time series derived from simultaneously recorded channels. We extract topological biomarkers from the signals via the computation of the persistent homology of time-evolving topological spaces. Remarkably, the proposed biomarkers robustly captures the change in the brain dynamics during the ictal state. We apply our methods in different types of signals including scalp and intracranial EEG and MEG, in patients during interictal and ictal states, showing high accuracy in a range of clinical situations. -
Geometric Feature Performance Under Downsampling for EEG Classification Tasks (2021)
Bryan Bischof, Eric BunchAbstract
We experimentally investigate a collection of feature engineering pipelines for use with a CNN for classifying eyes-open or eyes-closed from electroencephalogram (EEG) time-series from the Bonn dataset. Using the Takens' embedding--a geometric representation of time-series--we construct simplicial complexes from EEG data. We then compare \$\epsilon\$-series of Betti-numbers and \$\epsilon\$-series of graph spectra (a novel construction)--two topological invariants of the latent geometry from these complexes--to raw time series of the EEG to fill in a gap in the literature for benchmarking. These methods, inspired by Topological Data Analysis, are used for feature engineering to capture local geometry of the time-series. Additionally, we test these feature pipelines' robustness to downsampling and data reduction. This paper seeks to establish clearer expectations for both time-series classification via geometric features, and how CNNs for time-series respond to data of degraded resolution. -
Topology Highlights Mesoscopic Functional Equivalence Between Imagery and Perception: The Case of Hypnotizability (2019)
Esther Ibáñez-Marcelo, Lisa Campioni, Angkoon Phinyomark, Giovanni Petri, Enrica L. SantarcangeloAbstract
The functional equivalence (FE) between imagery and perception or motion has been proposed on the basis of neuroimaging evidence of large spatially overlapping activations between real and imagined sensori-motor conditions. However, similar local activation patterns do not imply the same mesoscopic integration of brain regions, which can be described by tools from Topological Data Analysis (TDA). On the basis of behavioral findings, stronger FE has been hypothesized in the individuals with high scores of hypnotizability scores (highs) with respect to low hypnotizable participants (lows) who differ between each other in the proneness to modify memory, perception and behavior according to specific imaginative suggestions. Here we present the first EEG evidence of stronger FE in highs. In fact, persistent homology shows that the highs EEG topological asset during real and imagined sensory conditions is significantly more similar than the lows. As a corollary finding, persistent homology shows lower restructuring of the EEG asset in highs than in lows during both sensory and imagery tasks with respect to basal conditions. Present findings support the view that greater embodiment of mental images may be responsible for the highs greater proneness to respond to sensori-motor suggestions and to report involuntariness in action. In addition, findings indicate hypnotizability-related sensory and cognitive information processing and suggest that the psycho-physiological trait of hypnotizability may modulate more than one aspect of the everyday life.