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Topographical Transcriptome Mapping of the Mouse Medial Ganglionic Eminence by Spatially Resolved RNA-seq
Sabrina Zechel, Pawel Zajac, Peter Lönnerberg, Carlos F. Ibáñez, Sten Linnarsson
Cortical interneurons originating from the medial ganglionic eminence, MGE, are among the most diverse cells within the CNS. Different pools of proliferating progenitor cells are thought to exist in the ventricular zone of the MGE, but whether the underlying subventricular and mantle regions of the MGE are spatially patterned has not yet been addressed. Here, we combined laser-capture microdissection and multiplex RNA-sequencing to map the transcriptome of MGE cells at a spatial resolution of 50 μm.