🍩 Database of Original & Non-Theoretical Uses of Topology
(found 3 matches in 0.001697s)
The Euler Characteristic: A General Topological Descriptor for Complex Data (2021)Alexander Smith, Victor Zavala
AbstractDatasets are mathematical objects (e.g., point clouds, matrices, graphs, images, fields/functions) that have shape. This shape encodes important knowledge about the system under study. Topology is an area of mathematics that provides diverse tools to characterize the shape of data objects. In this work, we study a specific tool known as the Euler characteristic (EC). The EC is a general, low-dimensional, and interpretable descriptor of topological spaces defined by data objects. We revise the mathematical foundations of the EC and highlight its connections with statistics, linear algebra, field theory, and graph theory. We discuss advantages offered by the use of the EC in the characterization of complex datasets; to do so, we illustrate its use in different applications of interest in chemical engineering such as process monitoring, flow cytometry, and microscopy. We show that the EC provides a descriptor that effectively reduces complex datasets and that this reduction facilitates tasks such as visualization, regression, classification, and clustering.
The Shape of Cancer Relapse: Topological Data Analysis Predicts Recurrence in Paediatric Acute Lymphoblastic Leukaemia (2021)Salvador Chulián, Bernadette J. Stolz, Álvaro Martínez-Rubio, Cristina Blázquez Goñi, Juan F. Rodríguez Gutiérrez, Teresa Caballero Velázquez, Águeda Molinos Quintana, Manuel Ramírez Orellana, Ana Castillo Robleda, José Luis Fuster Soler, Alfredo Minguela Puras, María Victoria Martínez Sánchez, María Rosa, Víctor M. Pérez-García, Helen Byrne
AbstractAcute Lymphoblastic Leukaemia (ALL) is the most frequent paediatric cancer. Modern therapies have improved survival rates, but approximately 15-20 % of patients relapse. At present, patients’ risk of relapse are assessed by projecting high-dimensional flow cytometry data onto a subset of biomarkers and manually estimating the shape of this reduced data. Here, we apply methods from topological data analysis (TDA), which quantify shape in data via features such as connected components and loops, to pre-treatment ALL datasets with known outcomes. We combine these fully unsupervised analyses with machine learning to identify features in the pre-treatment data that are prognostic for risk of relapse. We find significant topological differences between relapsing and non-relapsing patients and confirm the predictive power of CD10, CD20, CD38, and CD45. Further, we are able to use the TDA descriptors to predict patients who relapsed. We propose three prognostic pipelines that readily extend to other haematological malignancies. Teaser Topology reveals features in flow cytometry data which predict relapse of patients with acute lymphoblastic leukemia