🍩 Database of Original & Non-Theoretical Uses of Topology

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  1. The Persistence of Painting Styles (2025)

    Reetikaa Reddy Munnangi, Barbara Giunti
    Abstract Art is a deeply personal and expressive medium, where each artist brings their own style, technique, and cultural background into their work. Traditionally, identifying artistic styles has been the job of art historians or critics, relying on visual intuition and experience. However, with the advancement of mathematical tools, we can explore art through more structured lens. In this work, we show how persistent homology (PH), a method from topological data analysis, provides objective and interpretable insights on artistic styles. We show how PH can, with statistical certainty, differentiate between artists, both from different artistic currents and from the same one, and distinguish images of an artist from an AI-generated image in the artist's style.

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  2. Homology-Based Morphometry of Brain Atrophy: Methods and Applications (2026)

    Donato Quiccione, Mariam Pirashvili, Nathan Broomhead, Sean J. Fallon
    Abstract Understanding the structure of the brain, and how it changes with time and disease, is a core goal of structural neuroimaging. Contemporary approaches to structural brain analysis are dominated by voxel-wise, mass-univariate methods such as voxel-based morphometry (VBM). However, these techniques require images to be normalized to a standard template, which can obscure subject-specific geometric features. Normalization to a common stereotactic space can also be problematic when comparing groups with substantial brain pathology, lesions, or other anatomical abnormalities. Here, we introduce two complementary pipelines based on persistent homology (PH), a tool from topological data analysis, to quantify multiscale geometric features of structural T1-weighted MRI scans. Pipeline 1 quantifies regional thinning by applying the Euclidean distance transform to tissue masks in a slice-wise manner. Pipeline 2 uses \(\alpha\)-filtrations to measure structural similarity between pairs of scans, capturing sulcal widening and ventricular enlargement. Synthetic experiments with controlled induced lesions showed that Pipeline 1 is best suited to between-subject analyses, whereas Pipeline 2 is better suited to within-subject designs. Applied to real-world data from the Alzheimer's Disease Neuroimaging Initiative (ADNI), Pipeline 1 separated Alzheimer's disease (AD) from cognitively normal (CN) participants using single-modality T1-weighted MRI without nonlinear registration (ROC-AUC = 0.895), with peak effects localized to medial temporal regions. Pipeline 2 captured disease-related longitudinal change, with follow-up scans remaining closest to their own baselines and AD subjects showing greater short-interval change than CN subjects. Together, these pipelines provide interpretable topological biomarkers for cross-sectional group comparisons and longitudinal tracking.

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