🍩 Database of Original & Non-Theoretical Uses of Topology

(found 2 matches in 0.001042s)

  1. MRI and Biomechanics Multidimensional Data Analysis Reveals R2 -R1ρ as an Early Predictor of Cartilage Lesion Progression in Knee Osteoarthritis (2017)

    Valentina Pedoia, Jenny Haefeli, Kazuhito Morioka, Hsiang-Ling Teng, Lorenzo Nardo, Richard B. Souza, Adam R. Ferguson, Sharmila Majumdar
    Abstract PURPOSE: To couple quantitative compositional MRI, gait analysis, and machine learning multidimensional data analysis to study osteoarthritis (OA). OA is a multifactorial disorder accompanied by biochemical and morphological changes in the articular cartilage, modulated by skeletal biomechanics and gait. While we can now acquire detailed information about the knee joint structure and function, we are not yet able to leverage the multifactorial factors for diagnosis and disease management of knee OA. MATERIALS AND METHODS: We mapped 178 subjects in a multidimensional space integrating: demographic, clinical information, gait kinematics and kinetics, cartilage compositional T1ρ and T2 and R2 -R1ρ (1/T2 -1/T1ρ ) acquired at 3T and whole-organ magnetic resonance imaging score morphological grading. Topological data analysis (TDA) and Kolmogorov-Smirnov test were adopted for data integration, analysis, and hypothesis generation. Regression models were used for hypothesis testing. RESULTS: The results of the TDA showed a network composed of three main patient subpopulations, thus potentially identifying new phenotypes. T2 and T1ρ values (T2 lateral femur P = 1.45*10-8 , T1ρ medial tibia P = 1.05*10-5 ), the presence of femoral cartilage defects (P = 0.0013), lesions in the meniscus body (P = 0.0035), and race (P = 2.44*10-4 ) were key markers in the subpopulation classification. Within one of the subpopulations we observed an association between the composite metric R2 -R1ρ and the longitudinal progression of cartilage lesions. CONCLUSION: The analysis presented demonstrates some of the complex multitissue biochemical and biomechanical interactions that define joint degeneration and OA using a multidimensional approach, and potentially indicates that R2 -R1ρ may be an imaging biomarker for early OA. LEVEL OF EVIDENCE: 3 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2018;47:78-90.

  2. Using Multidimensional Topological Data Analysis to Identify Traits of Hip Osteoarthritis (2018)

    Jasmine Rossi‐deVries, Valentina Pedoia, Michael A. Samaan, Adam R. Ferguson, Richard B. Souza, Sharmila Majumdar
    Abstract Background Osteoarthritis (OA) is a multifaceted disease with many variables affecting diagnosis and progression. Topological data analysis (TDA) is a state-of-the-art big data analytics tool that can combine all variables into multidimensional space. TDA is used to simultaneously analyze imaging and gait analysis techniques. Purpose To identify biochemical and biomechanical biomarkers able to classify different disease progression phenotypes in subjects with and without radiographic signs of hip OA. Study Type Longitudinal study for comparison of progressive and nonprogressive subjects. Population In all, 102 subjects with and without radiographic signs of hip osteoarthritis. Field Strength/Sequence 3T, SPGR 3D MAPSS T1ρ/T2, intermediate-weighted fat-suppressed fast spin-echo (FSE). Assessment Multidimensional data analysis including cartilage composition, bone shape, Kellgren–Lawrence (KL) classification of osteoarthritis, scoring hip osteoarthritis with MRI (SHOMRI), hip disability and osteoarthritis outcome score (HOOS). Statistical Tests Analysis done using TDA, Kolmogorov–Smirnov (KS) testing, and Benjamini-Hochberg to rank P-value results to correct for multiple comparisons. Results Subjects in the later stages of the disease had an increased SHOMRI score (P \textless 0.0001), increased KL (P = 0.0012), and older age (P \textless 0.0001). Subjects in the healthier group showed intact cartilage and less pain. Subjects found between these two groups had a range of symptoms. Analysis of this subgroup identified knee biomechanics (P \textless 0.0001) as an initial marker of the disease that is noticeable before the morphological progression and degeneration. Further analysis of an OA subgroup with femoroacetabular impingement (FAI) showed anterior labral tears to be the most significant marker (P = 0.0017) between those FAI subjects with and without OA symptoms. Data Conclusion The data-driven analysis obtained with TDA proposes new phenotypes of these subjects that partially overlap with the radiographic-based classical disease status classification and also shows the potential for further examination of an early onset biomechanical intervention. Level of Evidence: 2 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2018;48:1046–1058.