@article{tebani_omics-based_2016, abstract = {The rise of technologies that simultaneously measure thousands of data points represents the heart of systems biology. These technologies have had a huge impact on the discovery of next-generation diagnostics, biomarkers, and drugs in the precision medicine era. Systems biology aims to achieve systemic exploration of complex interactions in biological systems. Driven by high-throughput omics technologies and the computational surge, it enables multi-scale and insightful overviews of cells, organisms, and populations. Precision medicine capitalizes on these conceptual and technological advancements and stands on two main pillars: data generation and data modeling. High-throughput omics technologies allow the retrieval of comprehensive and holistic biological information, whereas computational capabilities enable high-dimensional data modeling and, therefore, accessible and user-friendly visualization. Furthermore, bioinformatics has enabled comprehensive multi-omics and clinical data integration for insightful interpretation. Despite their promise, the translation of these technologies into clinically actionable tools has been slow. In this review, we present state-of-the-art multi-omics data analysis strategies in a clinical context. The challenges of omics-based biomarker translation are discussed. Perspectives regarding the use of multi-omics approaches for inborn errors of metabolism ({IEM}) are presented by introducing a new paradigm shift in addressing {IEM} investigations in the post-genomic era.}, author = {Tebani, Abdellah and Afonso, Carlos and Marret, Stéphane and Bekri, Soumeya}, date = {2016-09-14}, doi = {10.3390/ijms17091555}, issn = {1422-0067}, journaltitle = {International Journal of Molecular Sciences}, keywords = {1 - Bioinformatics, 1 - Machine learning, 1 - Mass spectrometry, 1 - Medicine, 1 - Metabolism, 2 - Clustering, 3 - Gene expression, 3 - Genomes, 3 - Transcriptomic profiling}, number = {9}, pmcid = {PMC5037827}, pmid = {27649151}, shortjournal = {Int J Mol Sci}, shorttitle = {Omics-Based Strategies in Precision Medicine}, title = {Omics-Based Strategies in Precision Medicine: Toward a Paradigm Shift in Inborn Errors of Metabolism Investigations}, url = {https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5037827/}, urldate = {2020-11-10}, volume = {17} }