@article{nardini_topological_2021, abstract = {Angiogenesis is the process by which blood vessels form from pre-existing vessels. It plays a key role in many biological processes, including embryonic development and wound healing, and contributes to many diseases including cancer and rheumatoid arthritis. The structure of the resulting vessel networks determines their ability to deliver nutrients and remove waste products from biological tissues. Here we simulate the Anderson-Chaplain model of angiogenesis at different parameter values and quantify the vessel architectures of the resulting synthetic data. Specifically, we propose a topological data analysis ({TDA}) pipeline for systematic analysis of the model. {TDA} is a vibrant and relatively new field of computational mathematics for studying the shape of data. We compute topological and standard descriptors of model simulations generated by different parameter values. We show that {TDA} of model simulation data stratifies parameter space into regions with similar vessel morphology. The methodologies proposed here are widely applicable to other synthetic and experimental data including wound healing, development, and plant biology.}, author = {Nardini, John T. and Stolz, Bernadette J. and Flores, Kevin B. and Harrington, Heather A. and Byrne, Helen M.}, date = {2021-06-28}, doi = {10.1371/journal.pcbi.1009094}, issn = {1553-7358}, journaltitle = {{PLOS} Computational Biology}, keywords = {1 - Angiogenesis, 1 - Cancer, 1 - Medicine, 1 - Neoplasm, 2 - Betti curves, 2 - Clustering, 2 - Persistence images, 2 - Persistent homology, 3 - images:2d, Innovate}, langid = {english}, note = {Publisher: Public Library of Science}, number = {6}, pages = {e1009094}, shortjournal = {{PLOS} Computational Biology}, title = {Topological data analysis distinguishes parameter regimes in the Anderson-Chaplain model of angiogenesis}, url = {https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1009094}, urldate = {2022-07-08}, volume = {17} }